Effects of intravenously infused Fluosol-DA 20% in rats
Identifieur interne : 001606 ( Main/Exploration ); précédent : 001605; suivant : 001607Effects of intravenously infused Fluosol-DA 20% in rats
Auteurs : Laurie West [États-Unis] ; Norma Mcintosh [États-Unis] ; Simona Gendler [États-Unis] ; Christine Seymour [États-Unis] ; Charlene Wisdom [États-Unis]Source :
- International Journal of Radiation Oncology, Biology, Physics [ 0360-3016 ] ; 1986.
English descriptors
- Teeft :
- Alkaline phosphatase, Clinical studies, Colloidal blood substitutes, Control animals, Control groups, Control levels, Days posttreatment, Dos, Emulsion, Fluosol, Foamy, Foamy macrophages, Ftpa, Hepatic, Hepatic enzymes, Histological analyses, Infusion, Lung tissues, Macrophage, Multiple doses, Multiple infusions, Organ weights, Perfluorochemical, Perfluorochemical emulsions, Phys, Radiation oncology, Relative organ weights, Spleen, Spleen weights, Treatment animals, Treatment groups, Weight gain, Whole body weights, Zuckscherdt verlag.
Abstract
Abstract: Rats were injected with a fractionated 50 ml/kg dose of Fluosol®-DA 20% with and without exposure to 100% oxygen. Animals were killed at 24, 43, 92, and 183 days post-treatment and samples taken for hematological, hepatic enzyme, histological, and perfluorochemical analyses. There were no significant differences in hemograms or hepatic enzyme findings between treatment and control groups. Differences in organ weights and histology were a result of perfluorochemical (PFC) accumulation in the tissues of treated animals. All changes were reversible. There were no effects from breathing high oxygen levels in either treatment or control animals.
Url:
DOI: 10.1016/0360-3016(86)90163-X
Affiliations:
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Le document en format XML
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Angeles</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Radiation Oncology, Biology, Physics</title><title level="j" type="abbrev">ROB</title><idno type="ISSN">0360-3016</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1986">1986</date><biblScope unit="volume">12</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1319">1319</biblScope><biblScope unit="page" to="1323">1323</biblScope></imprint><idno type="ISSN">0360-3016</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0360-3016</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Alkaline phosphatase</term><term>Clinical studies</term><term>Colloidal blood substitutes</term><term>Control animals</term><term>Control groups</term><term>Control levels</term><term>Days posttreatment</term><term>Dos</term><term>Emulsion</term><term>Fluosol</term><term>Foamy</term><term>Foamy macrophages</term><term>Ftpa</term><term>Hepatic</term><term>Hepatic enzymes</term><term>Histological analyses</term><term>Infusion</term><term>Lung tissues</term><term>Macrophage</term><term>Multiple doses</term><term>Multiple infusions</term><term>Organ weights</term><term>Perfluorochemical</term><term>Perfluorochemical emulsions</term><term>Phys</term><term>Radiation oncology</term><term>Relative organ weights</term><term>Spleen</term><term>Spleen weights</term><term>Treatment animals</term><term>Treatment groups</term><term>Weight gain</term><term>Whole body weights</term><term>Zuckscherdt verlag</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Rats were injected with a fractionated 50 ml/kg dose of Fluosol®-DA 20% with and without exposure to 100% oxygen. Animals were killed at 24, 43, 92, and 183 days post-treatment and samples taken for hematological, hepatic enzyme, histological, and perfluorochemical analyses. There were no significant differences in hemograms or hepatic enzyme findings between treatment and control groups. Differences in organ weights and histology were a result of perfluorochemical (PFC) accumulation in the tissues of treated animals. All changes were reversible. There were no effects from breathing high oxygen levels in either treatment or control animals.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="West, Laurie" sort="West, Laurie" uniqKey="West L" first="Laurie" last="West">Laurie West</name></region><name sortKey="Gendler, Simona" sort="Gendler, Simona" uniqKey="Gendler S" first="Simona" last="Gendler">Simona Gendler</name><name sortKey="Mcintosh, Norma" sort="Mcintosh, Norma" uniqKey="Mcintosh N" first="Norma" last="Mcintosh">Norma Mcintosh</name><name sortKey="Seymour, Christine" sort="Seymour, Christine" uniqKey="Seymour C" first="Christine" last="Seymour">Christine Seymour</name><name sortKey="Wisdom, Charlene" sort="Wisdom, Charlene" uniqKey="Wisdom C" first="Charlene" last="Wisdom">Charlene Wisdom</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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